Neural Coordination of Intestinal Motility and Mucosal Secretion of Water and Salt - Role in Toxin Induced Diarrhoea

Grant number: 400053

Abstract

This project deals with some of the basic mechanisms underlying disorders of gastrointestinal function and in particular with the mechanisms responsible for diarrhoea. Whenever there is a natural disaster (the recent tsunami for example) or a war, the breakdown of medical services leads to concern about outbreaks of cholera and other diarrhoea causing diseases, so understanding the mechanisms by which the cholera bacterium cause diarrhoea remains a major imperative. It is known that the diarrhoea resulting from cholera infection is produced by an enterotoxin, which acts to produce a massive over-secretion of water and salt through the intestinal wall, which if it is not controlled causes dea..

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Related publications (10)

Calcium sensing receptors mediate local inhibitory reflexes evoked by L-Phenylalanine in guinea pig jejunum

RM Gwynne, KDKN Ly, LJ Parry, JC Bornstein

2017-12-04

Amino acids applied to the mucosa evoke inhibitory reflexes in guinea-pig jejunum, but the receptors involved in sensory transduct..

Nitric oxide enhances inhibitory synaptic transmission and neuronal excitability in guinea-pig submucous plexus

JC Bornstein, KA Marks, JPP Foong, RM Gwynne, ZH Wang

2010-12-01

Varicosities immunoreactive for nitric oxide synthase (NOS) make synaptic connections with submucosal neurons in the guinea-pig sm..

The neurochemistry and innervation patterns of extrinsic sensory and sympathetic nerves in the myenteric plexus of the C57Bl6 mouse jejunum

LL Tan, JC Bornstein, CR Anderson

2010-03-17

In vitro anterograde tracing of axons in mesenteric nerve trunks using biotinamide in combination with immunohistochemical labelli..

5-HT1A, SST1, and SST2 receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum

JPP Foong, LJ Parry, RM Gwynne, JC Bornstein

2010-03-01

Vasoactive intestinal peptide (VIP) immunoreactive neurons are important secretomotor neurons in the submucous plexus. They are th..

Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurones in patients with idiopathic bile acid malabsorption

A Bajor, KA Ung, L Öhman, M Simren, EA Thomas, JC Bornstein, H Sjövall

2009-10-01

Aim: The interdigestive motor rhythm, the migrating motor complex (MMC), is accompanied by active secretion of chloride during per..

5-HT antagonists NAN-190 and SB 269970 block α2- adrenoceptors in the guinea pig

JPP Foong, JC Bornstein

2009-02-18

Serotonin (5-HT) plays a significant role in the regulation of intestinal secretion of water and electrolytes. The initial aim of ..

Strain-specific genetics, anatomy and function of enteric neural serotonergic pathways in inbred mice

KB Neal, LJ Parry, JC Bornstein

2009-02-12

Serotonin (5-HT) powerfully affects small intestinal motility and 5-HT-immunoreactive (IR) neurones are highly conserved between s..

Cholera Toxin Induces Sustained Hyperexcitability in Submucosal Secretomotor Neurons in Guinea Pig Jejunum

RM Gwynne, M Ellis, H Sjövall, JC Bornstein

2009-01-01

Background & Aims: Neural mechanisms underlying cholera toxin (CT)-induced intestinal hypersecretion remain unclear. We investigat..

Distinct chemical classes of medium-sized transient receptor potential channel vanilloid 1-immunoreactive dorsal root ganglion neurons innervate the adult mouse jejunum and colon

LL Tan, JC Bornstein, CR Anderson

2008-10-02

Physiological studies suggest visceral spinal afferents are generally small diameter, unmyelinated C-fibers or myelinated Aδ-fiber..

Insights into mechanisms of intestinal segmentation in guinea pigs: A combined computational modeling and in vitro study

JD Chambers, JC Bornstein, EA Thomas

2008-01-01

Segmentation in the guinea pig small intestine consists of a number of discrete motor patterns including rhythmic stationary contr..

University of Melbourne Researchers

Joel Bornstein